Manpower metabolism is principally mediated by the cytochrome P450 isoforms 3A4 (major route) and 2C9 (minor route). In rare instances, men have reported an erection that lasts many hours. In many cases, medical follow-up information was limited. At doses above the recommended dose range, adverse events were similar to those detailed above but generally were reported more frequently.The following events occurred in <2% of patients in controlled clinical trials; a causal relationship to Manpower is uncertain. For the 17 subjects who received Manpower 25 mg and matching placebo, the placebo-subtracted mean maximum decreases from baseline (95% CI) in systolic blood pressure were as follows:Blood pressure was measured immediately pre-dose and at 15, 30, 45 minutes, and 1, 1.5, 2, 2.5, 3, 4, 6 and 8 hours after Manpower or matching placebo. In the event of an erection that persists longer than 4 hours, the patient should seek immediate medical assistance. Manpower can help you get an erection when you are sexually excited. Manpower is not for newborns, children, or women. Male Extra #3. Manpower (sildenafil citrate) is formulated as blue, film-coated rounded-diamond-shaped tablets equivalent to 25 mg, 50 mg and 100 mg of Manpower for oral administration. Subjects who had successfully completed the previous doxazosin interaction study (using Manpower 50 mg), including no significant hemodynamic adverse events, were allowed to skip dose period 1. The pattern of responses was similar for the other principal question, the ability to achieve an erection sufficient for intercourse. On a global improvement question, 57% of Manpower patients reported improved erections versus 10% on placebo. There were no episodes of syncope reported in this study.When Manpower 100 mg oral was coadministered with amlodipine, 5 mg or 10 mg oral, to hypertensive patients, the mean additional reduction on supine blood pressure was 8 mmHg systolic and 7 mmHg diastolic.No significant interactions were shown with tolbutamide (250 mg) or warfarin (40 mg), both of which are metabolized by CYP2C9.Manpower (50 mg) did not potentiate the increase in bleeding time caused by aspirin (150 mg).Manpower (50 mg) did not potentiate the hypotensive effect of alcohol in healthy volunteers with mean maximum blood alcohol levels of 0.08%.In a study of healthy male volunteers, Manpower (100 mg) did not affect the steady state pharmacokinetics of the HIV protease inhibitors, saquinavir and ritonavir, both of which are CYP3A4 substrates.Manpower at steady state (80 mg t.i.d.) There was one subject with a decrease from baseline in standing systolic BP >30mmHg following Manpower 50 mg and one subject with a decrease from baseline in standing systolic BP > 30 mmHg following both Manpower 50 mg and placebo. On a global improvement question, 83% of patients reported improved erections on Manpower versus 12% on placebo. After sex is over, the erection goes away. Manpower is a pill used to treat erectile dysfunction (impotence) in men. What most men do not know is that giving your female partner sexual satisfaction is not automatic at all. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Talk online now with a doctor and get fast 1-on-1 answers from the comfort of your couch.We’re unable to offer personal health advice, but we’ve partnered with JustAnswer who offers on-demand doctors to answer your medical questions 24/7. This metabolite has a PDE selectivity profile similar to Manpower and an After either oral or intravenous administration, Manpower is excreted as metabolites predominantly in the feces (approximately 80% of administered oral dose) and to a lesser extent in the urine (approximately 13% of the administered oral dose).